This report from environmental NGO Friends of the Earth US outlines the health, environmental, ethical and consumer concerns associated with research into genetically engineered livestock. It notes that gene editing can lead to unintended effects, such as unintended modification of portions of DNA, enlarged tongues in rabbits, extra vertebrae in pigs, and novel proteins produced in error (which could result in allergic reactions).
Read the full report, Genetically engineered animals: From lab to factory farm, here. See also the report Gene-edited animals in agriculture and the Foodsource building block What is sustainable intensification?
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