Please login or create an account to join the discussion.

Fish-eaters, vegetarians and vegans have higher fracture risk

Image: holstein, Movement feet run, Pixabay, Pixabay Licence

This paper, by the Wellcome Trust-funded Oxford Livestock, Environment & People (LEAP) programme, finds that non-meat eaters, particularly vegans, have a higher total risk of bone fractures and some specific fracture types, such as hip fractures. After controlling for various confounding factors, the study finds that, relative to meat-eaters, vegans have a 2.31x higher risk of fractures; vegetarians have a 1.25x higher risk; and fish eaters have a 1.26x higher risk.

When the results were also adjusted to account for Body Mass Index (BMI), calcium intake and protein intake, vegans still had a 1.3x higher risk of total fractures than meat-eaters. In other words, adequate calcium and protein intake along with a higher BMI may be somewhat, but not fully, protective against higher fracture risk for vegans.

The study mostly considered white Europeans and may not be generalisable to other populations or ethnicities.




There is limited prospective evidence on possible differences in fracture risks between vegetarians, vegans, and non-vegetarians. We aimed to study this in a prospective cohort with a large proportion of non-meat eaters.


In EPIC-Oxford, dietary information was collected at baseline (1993–2001) and at follow-up (≈ 2010). Participants were categorised into four diet groups at both time points (with 29,380 meat eaters, 8037 fish eaters, 15,499 vegetarians, and 1982 vegans at baseline in analyses of total fractures). Outcomes were identified through linkage to hospital records or death certificates until mid-2016. Using multivariable Cox regression, we estimated the risks of total (n = 3941) and site-specific fractures (arm, n = 566; wrist, n = 889; hip, n = 945; leg, n = 366; ankle, n = 520; other main sites, i.e. clavicle, rib, and vertebra, n = 467) by diet group over an average of 17.6 years of follow-up.


Compared with meat eaters and after adjustment for socio-economic factors, lifestyle confounders, and body mass index (BMI), the risks of hip fracture were higher in fish eaters (hazard ratio 1.26; 95% CI 1.02–1.54), vegetarians (1.25; 1.04–1.50), and vegans (2.31; 1.66–3.22), equivalent to rate differences of 2.9 (0.6–5.7), 2.9 (0.9–5.2), and 14.9 (7.9–24.5) more cases for every 1000 people over 10 years, respectively. The vegans also had higher risks of total (1.43; 1.20–1.70), leg (2.05; 1.23–3.41), and other main site fractures (1.59; 1.02–2.50) than meat eaters. Overall, the significant associations appeared to be stronger without adjustment for BMI and were slightly attenuated but remained significant with additional adjustment for dietary calcium and/or total protein. No significant differences were observed in risks of wrist or ankle fractures by diet group with or without BMI adjustment, nor for arm fractures after BMI adjustment.


Non-meat eaters, especially vegans, had higher risks of either total or some site-specific fractures, particularly hip fractures. This is the first prospective study of diet group with both total and multiple specific fracture sites in vegetarians and vegans, and the findings suggest that bone health in vegans requires further research.



Tong, T.Y., Appleby, P.N., Armstrong, M.E., Fensom, G.K., Knuppel, A., Papier, K., Perez-Cornago, A., Travis, R.C. and Key, T.J., 2020. Vegetarian and vegan diets and risks of total and site-specific fractures: results from the prospective EPIC-Oxford study. BMC medicine, 18(1), pp.1-15.


Read the full paper here. See also the Table explainer What is a healthy sustainable eating pattern?

Post a new comment »

Login or register to comment with your personal account. Anonymous comments require approval to be visible.